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Article

HLA class I escape drives the evolution of SARS-CoV-2 in human populations.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2026

Riumina Ekaterina D, Alekseeva Evgeniia I, Klink Galya V, Feigin Stepan, Vinogradova Iaroslava, Ivanova Natalia, Dianov Dmitry, Zornikova Ksenia, Davydova Vassa, Bogolyubova Apollinariya, Bazykin Georgii A

Abstract excerpt

The role of escape from the cytotoxic T cell (CTL) response in Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) evolution remains controversial. Here, we study the origin and spread of SARS-CoV-2 variants whose mutations reduce presentation by the human leukocyte antigen (HLA) class I alleles common in human populations. We find that 35% of mutations that are characteristic of the variants of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42636373
DOI: 10.1073/pnas.2619192123
PMCID: PMC13534678

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