Article

SARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes

2020-12-20

Abstract excerpt

CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control, though direct evidence has been lacking so far. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV- 2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding, which was associated with a loss of recognition and functional res...

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Identifiers and source

Literature Corpus work: 0dc175de-d026-5172-826f-8fd5c89eae79
DOI: 10.1101/2020.12.18.423507

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