Article

Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host

2025-05-28

Abstract excerpt

Persistent SARS-CoV-2 infection in immunocompromised patients creates a unique environment for the accumulation of mutations linked to immune evasion. This is due to prolonged virus-host interaction, coupled with the effects of diminished selective pressures resulting from suboptimal adaptive immunity. In this study, we investigated viral evolution and immune escape during a 2.5-year persistent SARS-CoV-2 infectio...

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Literature Corpus work: 073e540d-2442-5d0b-af16-0b6298ad4855
DOI: 10.1101/2025.05.28.25328480

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