Article

Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope

2021-06-28

Abstract excerpt

<h4>ABSTRACT</h4> The adaptive immune system protects against infection via selection of specific antigen receptors on B-cells and T-cells. We studied the prevalent CD8 ‘killer’ T-cell response mounted against SARS-CoV-2 Spike 269-277 epitope YLQPRTFLL via the most frequent Human Leukocyte Antigen (HLA) class I worldwide, HLA A*02. The widespread Spike P272L mutation has arisen in at least 14 different SARS-CoV-2...

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Literature Corpus work: 616880f9-0043-584a-803e-00f5642235a3
DOI: 10.1101/2021.06.21.21259010

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