Article

The Impact of Viral Mutations on Recognition by SARS-CoV-2 Specific T-Cells

2021-05-12

Abstract excerpt

We identify amino acid variants within dominant SARS-CoV-2 T-cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T-cells assessed by IFN-γ and cytotoxic killing assays. These data demonstrate the potential for T-cell evasion and highlight the need for ongoing...

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Literature Corpus work: 5ac97acc-9781-515c-8695-dfcc0c57a4e0
DOI: 10.2139/ssrn.3844713

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