Population-level toggling of T cell immune escape at human leukocyte antigen anchor residues in SARS-CoV-2 Spike proteins, in an ethnically diverse population region.

doi:10.1371/journal.pcbi.1013261

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Article

Population-level toggling of T cell immune escape at human leukocyte antigen anchor residues in SARS-CoV-2 Spike proteins, in an ethnically diverse population region.

PLoS computational biology - 1 Jul 2025

Ngandu Nobubelo K, Fielding Burtram C, van Heusden Peter, Mcinga Kuhle, Francis Kriheska, Harkins Gordon

Abstract excerpt

There is currently limited understanding of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) adaptation to the human leukocyte antigen (HLA) proteins which mediate CD8 (HLA-I) and CD4 (HLA-II) T cell immune responses. We investigated population-level T cell immune escape in SARS-CoV-2 Spike protein at amino acid binding positions (the anchor motifs) preferred by the highly restrictive peptide...

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Topics

Humans
Spike Glycoprotein, Coronavirus
SARS-CoV-2
COVID-19
Immune Evasion
HLA Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Epitopes, T-Lymphocyte

South Africa

Mutation

Phylogeny

Amino Acid Motifs

Amino Acid Sequence

T-Lymphocytes

Source

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Identifiers

PMID: 40690526
DOI: 10.1371/journal.pcbi.1013261
PMCID: PMC12303384

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