Article
Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease.
European heart journal - 24 Jan 2026
von Scheidt Moritz, Adkar Shaunak S, Krefting Johannes, Hoermann Gregor, Meggendorfer Manja, Bauer Sabine, Mitchell Shaneice, Pugach Irina, Friess Christian, Ma Angela, Hao Ke, Steigerwald Sophia, Wahle Maria, Kessler Thorsten, Schwab Marius, Voll Felix, Mokry Michal, Sofokleous Charalampos, Palm Kaylin C A, Bongiovanni Dario, Fleig Julia, Oldenbuettel Lilith, Chen Zhifen, Hecker Judith S, Bassermann Florian, Maegdefessel Lars, Graw Matthias, Ruusalepp Arno, Hilgendorf Ingo, Leuschner Florian, Sager Hendrik B, Heimlich J Brett, Koenig Wolfgang, Cremer Sebastian, Leistner David M, Abplanalp Wesley T, Dimmeler Stefanie, Zeiher Andreas M, van der Laan Sander W, Pasterkamp Gerard, Braun Christian, Jaiswal Siddhartha, Kovacic Jason C, Kern Wolfgang, Haferlach Claudia, Mann Matthias, Cassese Salvatore, Kastrati Adnan, Haferlach Torsten, Leeper Nicholas J, Björkegren Johan L M, Schunkert Heribert
Abstract excerpt
BACKGROUND AND AIMS: Clonal haematopoiesis of indeterminate potential (CHIP) has been associated with cardiovascular risk, but its prognostic relevance and mechanistic role in coronary artery disease (CAD) remains incompletely understood. This study investigated the association between CHIP and all-cause mortality in CAD and explored the cellular and molecular mechanisms, focusing on TET2 mutations. METHODS:...
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