Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis.

doi:10.1093/cvr/cvaf210

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Article

Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis.

Cardiovascular research - 18 Dec 2025

Örd Tiit, Palani Senthil, Giroud Gerbetant Judith, Bodoy Susanna, Lönnberg Tapio, Niskanen Henri, Ravindran Aarthi, Holappa Lari, Chemaly Melody, Taipale Mari, Õunap Kadri, Haikonen Retu, Talukdar Husain, Sukhavasi Katyayani, Liljenbäck Heidi, Virta Jenni, Ruotsalainen Anna-Kaisa, Pierrot-Blanchet Clara, Miner Maxwell W G, Moisio Olli, Rajala Noora, Li Xiang-Guo, Low Philip S, Saraste Antti, Heinäniemi Merja, Ylä-Herttuala Seppo, Björkegren Johan L M, Hedin Ulf, Matic Ljubica, Yvan-Charvet Laurent, Palacín Manuel, Roivainen Anne, Kaikkonen Minna U

Abstract excerpt

AIMS: Atherosclerosis is a major global health challenge, with limited diagnostic and therapeutic options. Macrophages drive disease progression, but their tissue-specific phenotypes and functions remain poorly defined. This study aims to elucidate macrophage-driven mechanisms by characterizing their functional diversity across key metabolic and vascular tissues. METHODS AND RESULTS: We used single-cell RNA...

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PMID: 41206594
DOI: 10.1093/cvr/cvaf210
PMCID: PMC12713647

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