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Article

Functional Subsets of Plasma Cells Associated with Amyloid Production and Venetoclax Sensitivity in Light Chain Amyloidosis

2022-05-09

Abstract excerpt

<title>Abstract</title> <p>Light-chain amyloidosis (AL) is characterised by a systematic deposition of amyloidogenic immunoglobulin light chains produced by pathogenic bone marrow plasma cells (BMPCs), the features of which remain elusive. Herein, we conducted a single-cell RNA-seq and image flow cytometry analysis of BMPCs in AL in comparison with those in healthy controls and their precursors: monoclonal gammop...

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Literature Corpus work
31134c48-4ec5-57eb-88d5-6e785026a4b4
DOI
10.21203/rs.3.rs-1609283/v1
Open publication

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