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Article

miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis.

Gastroenterology - 1 Jan 2022

Ge Wenjie, Goga Algera, He Yuliang, Silva Pamuditha N, Hirt Christian Kurt, Herrmanns Karolin, Guccini Ilaria, Godbersen Svenja, Schwank Gerald, Stoffel Markus

Abstract excerpt

BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor that is almost uniformly lethal in humans. Activating mutations of KRAS are found in >90% of human PDACs and are sufficient to promote acinar-to-ductal metaplasia (ADM) during tumor initiation. The roles of miRNAs in oncogenic Kras-induced ADM are incompletely understood. METHODS: The Ptf1aCre/+LSL-KrasG12D/+ and...

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PMID: 34547282
DOI: 10.1053/j.gastro.2021.09.029

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