Signatures of nonsense-mediated mRNA decay but no evidence for transcriptional adaptation associated with protein-truncating variants in wild yeast diploids.

Abstract excerpt

Transcriptional adaptation (TA) is a regulatory process in which loss or disruption of gene function caused by protein-truncating variants (PTVs) triggers compensatory changes in expression of the healthy allele or in expression of related genes. Nonsense-mediated mRNA decay (NMD), a conserved RNA surveillance pathway that degrades transcripts containing premature termination codons, is required to initiate this...

Topics

• Nonsense Mediated mRNA Decay
• Saccharomyces cerevisiae
• Transcription, Genetic
• Codon, Nonsense
• Mutation
• Gene Expression Regulation, Fungal