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Article

Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay.

BMC biology - 14 May 2009

Zhang Zhenguo, Xin Dedong, Wang Ping, Zhou Li, Hu Landian, Kong Xiangyin, Hurst Laurence D

Abstract excerpt

BACKGROUND: Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature termination codons at fixation is paradoxical: why make a transcript if it is only to be destroyed? One model supposes that splicing is inherently noisy and spurious transcripts are common. The evolution of a premature termination codon in a regularly made unwanted transcript...

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Identifiers

PMID: 19442261
DOI: 10.1186/1741-7007-7-23
PMCID: PMC2697156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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