Article
The genomic landscape of compensatory evolution.
PLoS biology - 1 Aug 2014
Szamecz Béla, Boross Gábor, Kalapis Dorottya, Kovács Károly, Fekete Gergely, Farkas Zoltán, Lázár Viktória, Hrtyan Mónika, Kemmeren Patrick, Groot Koerkamp Marian J A, Rutkai Edit, Holstege Frank C P, Papp Balázs, Pál Csaba
Abstract excerpt
Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects through compensatory genetic changes. This process can potentially influence directions of adaptive evolution by enabling evolutionary routes that are otherwise...
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