Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional homeostasis: a mechanism of protein quality control.

Medical hypotheses - 1 Jan 2004

Sallie Richard

Abstract excerpt

Sickle cell anaemia confirms that minor mutations in protein sequence can have catastrophic effects. However, RNA transcription depends on polymerases that have low fidelity and introduce errors at a rate of 10(-5) substitutions/base synthesised. For many large proteins translation of these errors could result in significant loss of function, while for others (for example, cell surface signalling proteins)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed RNA Polymerases
Share to Gene Expression Regulation
Share to Homeostasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Mutation

Share to Transcription, Genetic

Source

Identifiers

PMID: 15236780
DOI: 10.1016/j.mehy.2004.02.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional homeostasis: a mechanism of protein quality control.PMID 15236780Read ↗

The hidden costs of imperfection: transcription errors in protein aggregation diseases.Semantic proximity Read ↗

Transcription errors induce proteotoxic stress and shorten cellular lifespan.Semantic proximity Read ↗

The landscape of transcription errors in eukaryotic cells.Semantic proximity Read ↗

Expression level, evolutionary rate, and the cost of expression.Semantic proximity Read ↗

Evolutionary conservation of the fidelity of transcriptionSemantic proximity Read ↗

Functional effects of protein variants.Semantic proximity Read ↗

Whisper mutations: cryptic messages within the genetic code.Semantic proximity Read ↗

RNA polymerase errors cause splicing defects and can be regulated by differential expression of RNA polymerase subunits.Semantic proximity Read ↗

Cytoplasmic import and processing of mRNA amplify transcriptional bursts accounting for the majority of cellular noiseSemantic proximity Read ↗

Protein mistranslation: friend or foe?Semantic proximity Read ↗

Robust Yet Fragile: Expression Noise, Protein Misfolding, and Gene Dosage in the Evolution of Genomes.Semantic proximity Read ↗

Genome stability versus transcript diversity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.