Functionality versus Adaptation: Insights from Transcriptional Adaptation.

Abstract excerpt

Transcriptional adaptation (TA) works through a mechanism in which ILF3 binds degradation fragments of aberrant mRNAs and upregulates a sequence-related "adapting gene" for expressional compensation. It is worth thinking whether the entire TA mechanism can be regarded as adaptive given its potential off-targeting, sensitivity to mutations, reliance on paralogous genes, and the counterproductive self-TA. Here, we...

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