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Article

Unveiling the Immune Mechanisms of Hypertension With Single-Cell Transcriptome-Wide Mendelian Randomization.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 Aug 2026

Mao Yukang, Li Peng, Cheng Chen, Kong Xiangqing, Sun Wei, Wu Tingting

Abstract excerpt

Immune dysregulation is closely implicated in hypertension pathogenesis, yet specific therapeutic targets are lacking. We integrated expression quantitative trait loci (eQTLs) for genes expressed in 14 immune cell subsets (OneK1K) with two-sample Mendelian randomization (MR) and colocalization to provide evidence for cell type-specific causal effects of eGenes (genes with eQTLs) on hypertension and related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42622622
DOI: 10.1096/fj.202600899R
PMCID: PMC13492368

Genes

CD4
CTSW
DDX5
FNBP4
PRELID1
VIM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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