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Deciphering genetic associations with blood pressure in peripheral blood mononuclear cells through single-cell transcriptomic profiling.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Nov 2025

Zhang Huan, Fan Kedi, Jia Shuanglong, Gao Qianyi, Zhang Zhentao, Long Jianing, Li Dianyuan, Mo Xingbo

Abstract excerpt

Functional genes within genomic loci associated with blood pressure (BP) identified by genome-wide association studies (GWASs) are cell type-specific. This study aims to identify such genes in immune cells by employing single-cell transcriptomic analysis in peripheral blood mononuclear cells (PBMCs). By integration of single-cell transcriptomic sequencing data with GWAS (1 million individuals) findings using the...

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PMID: 40877473
DOI: 10.1038/s41440-025-02344-3

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ERAP2

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