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Article

Integrative mendelian randomization approaches for therapeutic target prioritisation in immune-mediated diseases.

Scientific reports - 3 Mar 2026

Sobczyk Maria K, Gaunt Tom R

Abstract excerpt

Immune-mediated diseases (IMD) encompass a wide range of autoimmune and inflammatory disorders with aetiology related to immune system dysfunction, signifying a disease area with great potential for drug repurposing. In this study, we employed the genetically informed Mendelian Randomization (MR) method with two distinct exposure types: immune blood cell abundance and protein quantitative trait loci (pQTL) to...

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Identifiers

PMID: 41775781
DOI: 10.1038/s41598-026-41818-3
PMCID: PMC13065838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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