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Article

FES eQTL suppresses the progression of primary aldosteronism by regulating CD3 on TD CD8br immune cells: Mendelian randomization and mediation analysis.

Mammalian genome : official journal of the International Mammalian Genome Society - 11 May 2026

Deng Cai, Liao Huasheng, Wu Yizhao, Ao Zijian, Zhang Lichao

Abstract excerpt

The pathogenesis of primary aldosteronism (PA) remains incompletely understood. Current pharmacological therapies have significant limitations, thus highlighting the importance of recognizing new therapeutic targets for the diagnosis and treatment of PA. This study employed two-sample Mendelian randomization (MR) analysis, colocalization, summary data-based Mendelian randomization (SMR) analysis, and mediation...

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Share to CD3 Complex
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Expression Regulation

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 42115443
DOI: 10.1007/s00335-026-10235-2

Genes

FES

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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