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Article

Exploring the shared genetic architecture of sarcopenia using genomic structural equation modeling.

The journals of gerontology. Series A, Biological sciences and medical sciences - 5 Sept 2026

Li Yusheng, Zhang Peizhen, Chen Qiaoling, Zhang Jiacheng, Wang Hongyi, Zhang Wei, Li Huanan, Wang Jingui

Abstract excerpt

Sarcopenia is a common age-associated condition characterized by the progressive loss of skeletal muscle mass, strength, and physical functionality. While large-scale genome-wide association studies (GWAS) have previously addressed isolated traits of sarcopenia, the multifactorial genetic architecture underlying this condition remains largely undefined. To characterize the common genetic basis of...

Read the complete abstract on PubMed

Topics

Sarcopenia
Humans
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Genetic Risk Score
Genetic Predisposition to Disease

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Identifiers

PMID: 42615996
DOI: 10.1093/gerona/glag204

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