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Article

Genome-wide association study of sarcopenia index reveals sex-stratified genetic architecture.

Biology of sex differences - 25 Aug 2026

Mu Yumeng, Liao Binzhi, Luo Mengliang, Lu Kaifeng, Tang Huaxin, Nie Mao, Sun Xianding

Abstract excerpt

BACKGROUND: The sarcopenia index (SI), defined as the ratio of serum creatinine to cystatin C, is a proposed biomarker of muscle mass and sarcopenia, yet its genomic basis and genetic architecture remain largely unexplored. METHODS: We performed combined-sex and sex-stratified genome-wide association studies of SI in the UK Biobank. We examined the overlap between SI-associated loci and loci previously reported...

Read the complete abstract on PubMed

Topics

Humans
Sarcopenia
Male
Genome-Wide Association Study
Female
Sex Characteristics
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

UK Biobank

Creatinine

Cystatin C

Source

Open in PubMed Open full text

Identifiers

PMID: 42702734
DOI: 10.1186/s13293-026-00973-y
PMCID: PMC13548639

Genes

SI
GATM
ESR1
GATA4
MYOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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