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Multi-trait Genome-Wide Analysis Identified 20 Novel Loci for Sarcopenia-Related Traits in UK Biobank.

Calcified tissue international - 3 Jan 2025

Ran Shu, Lin XiTong, Wang SiQi, Li ZhuoQi, Liu BaoLin

Abstract excerpt

This study aims to identify novel loci associated with sarcopenia-related traits in UK Biobank (UKB) through multi-trait genome-wide analysis. To identify novel loci associated with sarcopenia, we integrated the genome-wide association studies (GWAS) of usual walking pace (UWP) and hand grip strength (HGS) to conduct a joint association study known as multi-trait analysis of GWAS (MTAG). We performed a...

Topics

Humans
Sarcopenia
Genome-Wide Association Study
United Kingdom
Biological Specimen Banks
Hand Strength
Male
Muscle, Skeletal
Transcriptome
Female
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

Aged

UK Biobank

Source

Identifiers

PMID: 39751833
DOI: 10.1007/s00223-024-01312-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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