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Dissecting Immune Mechanisms Underlying Sarcopenia Using Multi-omics Approaches.

Calcified tissue international - 2 May 2026

Ding Kaixi, Jiang Wei, Lei Ming, Gao Yongxiang

Abstract excerpt

Sarcopenia is an age-related muscle disease, and its gene regulation in immune cells is not well understood. Using immune cell-specific single-cell expression quantitative trait loci (sc-eQTLs), genome-wide association studies (GWAS), and multi-omics data, we systematically explored their potential causal roles in sarcopenia. We integrated sc-eQTL and cis-eQTL data from whole blood and skeletal muscle, seven...

Topics

Humans
Sarcopenia
Multiomics
Genome-Wide Association Study
Quantitative Trait Loci
Muscle, Skeletal
Genetic Predisposition to Disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 42068367
DOI: 10.1007/s00223-026-01524-8

Genes

SLC22A5
FNBP4
C5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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