Whole-exome sequencing and genome-wide association studies identify novel sarcopenia risk genes in Han Chinese.

Abstract excerpt

Sarcopenia is a complex polygenic disease, and its molecular mechanism is still unclear. Whole lean body mass (WLBM) is a heritable trait predicting sarcopenia. To identify genomic loci underlying, we performed a whole-exome sequencing (WES) of WLBM variation with high sequencing depth (more than 40*) in 101 Chinese subjects. We then replicated in the major findings in the large-scale UK Biobank (UKB) cohort...

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• Body Mass Index
• China
• Exome
• Genetic Pleiotropy
• Polymorphism, Single Nucleotide