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Article

Genomic structural equation modeling reveals the shared genetic architecture of osteosarcopenia across five musculoskeletal phenotypes.

Mammalian genome : official journal of the International Mammalian Genome Society - 21 May 2026

Lai Weiqiang, Gong Kaiqin, Zhong Ronghao, Yin Weicong, Li Xu, He Xinhuang, Hu Siyuan, Chen Chuqun, He Kunrui, Sun Chunhan, Zheng Jianping, Zeng Guowei

Abstract excerpt

Osteosarcopenia-the concurrent presence of osteoporosis and sarcopenia-affects approximately 18.5% of older adults globally, yet its shared genetic basis remains poorly understood. We applied genomic structural equation modeling (Genomic SEM) to integrate genome-wide association study (GWAS) summary statistics across five phenotypes spanning the pathophysiological spectrum of osteosarcopenia: appendicular lean...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42166073
DOI: 10.1007/s00335-026-10245-0

Genes

HGS
ACAN
BMP6
CFI
FOXO3
IGF1R
IHH
IRS1
LRP5
SOX5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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