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Article

Integrating genetics and transcriptome analyses identify potential biomarkers and immune interactions in metabolic syndrome-related sarcopenia.

Journal of translational medicine - 5 Nov 2025

Fu Wei, Chang Ning, Liang Han, Xu Rong, Yang Kaikai, Li Xu, Wang Xiaoming

Abstract excerpt

BACKGROUND: Increasing evidence has indicated that metabolic syndrome (MetS) exists in a close link with sarcopenia; however, the potential mechanism and biomarkers between them remain uninvestigated. This study leverages integrative genetics and transcriptome to identify potential biomarkers and immune interactions in MetS-related sarcopenia. METHODS: We used genome-wide association studies summary statistics...

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Identifiers

PMID: 41194111
DOI: 10.1186/s12967-025-07191-x
PMCID: PMC12590666

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