Article
Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study.
International journal of epidemiology - 18 Aug 2026
Chen Siyu, Liang Yiwen, Luo Shan, Zheng Jie, Yoshiji Satoshi, Power Grace M, Xu Zikun, Burgess Stephen, Cowling Benjamin John, Lam Hugh Simon, Li Albert Martin, Leung Gabriel Matthew, Schooling Catherine Mary, Au Yeung Shiu Lun
Abstract excerpt
BACKGROUND: Increased childhood adiposity contributes to higher type 2 diabetes (T2D) risk, but the underlying mechanisms remain unclear. Furthermore, whether these mechanistic pathways are shared across ethnic groups has not been explored. METHODS: We conducted a two-step Mendelian randomization (MR) using European-based summary statistics from genome-wide association studies of childhood body mass index (BMI)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.