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Article

Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study.

American journal of hypertension - 1 Jan 2026

Zhang Yuying, Lin Zikai, He Xuyu, Lu Jialin, Tan Peishan, Huang Qinyao, Zhang Kunyi

Abstract excerpt

BACKGROUND: The relationship between childhood and adulthood obesity and the risk of gestational diabetes mellitus (GDM) remains unclear. To clarify the independent and joint effects of childhood and adulthood body size on GDM risk, and explore inflammation's role. METHODS: Using female-specific UK Biobank genome-wide association study data, genetic instruments for childhood/adult body size ("thinner," "about...

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PMID: 40908541
DOI: 10.1093/ajh/hpaf154

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