Article
Phenome-Wide Investigation of the Causal Associations Between Pre-Pregnancy Obesity Traits and Gestational Diabetes: A Two-Sample Mendelian Randomization Analyses.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2025
Hu Mengjin, Li Xiaosong, Wu Jiangong, Li Boyu, Xia Jinggang, Yang Yuejin, Yin Chunlin
Abstract excerpt
Pre-pregnancy obesity was associated with gestational diabetes in observational studies, but whether this relationship is causal remains to be determined. To evaluate whether pre-pregnancy obesity traits causally affect gestational diabetes risk, a two-sample Mendelian randomization (MR) analysis was performed utilizing summary-level statistics from published genome-wide association studies (GWAS)....
Topics
- Humans
- Female
- Pregnancy
- Mendelian Randomization Analysis
- Diabetes, Gestational
- Obesity
- Genome-Wide Association Study
- Body Mass Index
- Phenotype
- Risk Factors