Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Transcriptome-Wide Association Study Identifies USP36 as a Potential Therapeutic Target for Heart Failure.

Drug research - 1 Sept 2026

Yu Kefu, Meng Qiuxiao, Jiang Wenshuo, Zhao Zhigang, Yang Li

Abstract excerpt

Background: Heart failure is a significant global health burden. This study aims to identify heart failure-associated genes through transcriptome-wide association studies combined with genome-wide association studies. Methods: A transcriptome-wide association study was conducted using Functional Summary-based Imputation, integrating heart failure genome-wide association study summary data (47,309 cases and...

Read the complete abstract on PubMed

Topics

Heart Failure
Genome-Wide Association Study
Humans
Molecular Docking Simulation
Transcriptome
Oxidative Stress

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Ubiquitin Thiolesterase

Quantitative Trait Loci

Polymorphism, Single Nucleotide

Apoptosis

Source

Identifiers

PMID: 42607999
DOI: 10.1055/a-2897-9774

Genes

USP36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 27 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Transcriptome-Wide Association Study Identifies USP36 as a Potential Therapeutic Target for Heart Failure.PMID 42607999Read ↗

Multi-trait genome-wide analysis identified novel risk loci and candidate drugs for heart failureSemantic proximity Read ↗

Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction.Semantic proximity Read ↗

Genome-wide association and multi-omic analyses reveal new mechanisms for Heart FailureSemantic proximity Read ↗

Identifying OGN as a Biomarker Covering Multiple Pathogenic Pathways for Diagnosing Heart Failure: From Machine Learning to Mechanism InterpretationSemantic proximity Read ↗

Dissecting Regulatory Non-Coding Heart Disease GWAS Loci with High-Resolution 3D Chromatin Interactions Reveals Causal Genes with Pathophysiological Relevance to Heart FailureSemantic proximity Read ↗

Large-scale Mendelian randomization identifies novel pathways as therapeutic targets for heart failure with reduced ejection fraction and with preserved ejection fractionSemantic proximity Read ↗

Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure.Semantic proximity Read ↗

Dissecting Regulatory Non-Coding GWAS Loci Reveals Fibroblast Causal Genes with Pathophysiological Relevance to Heart FailureSemantic proximity Read ↗

Integrative analyses of biomarkers and pathways for heart failureSemantic proximity Read ↗

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failureSemantic proximity Read ↗

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failureSemantic proximity Read ↗

RNA-seq driven expression and enrichment analysis to investigate CVD genes with associated phenotypes among high-risk heart failure patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.