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Article

MAXTIA: A high-throughput platform for rapid functional epitope mapping by kinetic screening of mutant libraries.

Protein science : a publication of the Protein Society - 1 Sept 2026

Kim Kihoon, Matsunaga Ryo, Yokoo Takanori, Nakakido Makoto, Tsumoto Kouhei

Abstract excerpt

Accurate identification of epitope residues is essential for developing biopharmaceuticals and understanding the mechanisms of immune recognition. However, experimental approaches for residue-level epitope mapping remain time-consuming and labor-intensive, while accurate computational prediction of protein-protein interfaces remains challenging. Here, we present MAXTIA, a high-throughput kinetic screening...

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Identifiers

PMID: 42606277
DOI: 10.1002/pro.70769
PMCID: PMC13479966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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