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Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing

22 Aug 2015

Abstract excerpt

Knowledge of the fine location of neutralizing and non-neutralizing epitopes on human pathogens affords a better understanding of the structural basis of antibody efficacy, which will expedite rational design of vaccines, prophylactics, and therapeutics. However, full utilization of the wealth of information from single cell techniques and antibody repertoire sequencing awaits the development of a high...

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PMID: 26296891
DOI: 10.1074/jbc.m115.676635

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