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Article

Environment shapes gut microbiome and determines susceptibility to DSS-colitis in Adamdec1-/- mice.

Frontiers in immunology - 1 Jan 2026

Kumagai Tomoko, Rath Silke, Fan Shuangqi, Rahman Farooq Z, Smith Andrew M

Abstract excerpt

Background: Inflammatory bowel disease (IBD) is characterized by marked clinical heterogeneity, reflecting complex interactions between host genetics, environmental exposures, and the gut microbiome. Although over 300 genetic risk loci have been identified, these account for only a fraction of disease variance, highlighting the importance of gene-environment interactions. ADAM-like Decysin-1 (ADAMDEC1) is a...

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Identifiers

PMID: 42577386
DOI: 10.3389/fimmu.2026.1824007
PMCID: PMC13454422

Genes

ADAMDEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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