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Differential colitis susceptibility of Th1- and Th2-biased mice: A multi-omics approach

9 Mar 2022

Abstract excerpt

The health and economic burden of colitis is increasing globally. Understanding the role of host genetics and metagenomics is essential to establish the molecular basis of colitis pathogenesis. In the present study, we have used a common composite dose of DSS to compare the differential disease severity response in C57BL/6 (Th1 biased) and BALB/c (Th2 biased) mice with zero mortality rates. We employed...

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PMID: 35263357
DOI: 10.1371/journal.pone.0264400

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