Article
Dissecting the respective roles of microbiota and host genetics in the susceptibility of Card9-/- mice to colitis.
Microbiome - 23 Apr 2024
Danne C, Lamas B, Lavelle A, Michel M-L, Da Costa G, Pham Hang-Phuong, Lefevre A, Bridonneau C, Bredon M, Planchais J, Straube M, Emond P, Langella P, Sokol H
Abstract excerpt
BACKGROUND: The etiology of inflammatory bowel disease (IBD) is unclear but involves both genetics and environmental factors, including the gut microbiota. Indeed, exacerbated activation of the gastrointestinal immune system toward the gut microbiota occurs in genetically susceptible hosts and under the influence of the environment. For instance, a majority of IBD susceptibility loci lie within genes involved in...
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