Article
Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.
Gastroenterology - 1 Jul 2014
Li Haiying, Chan Lillienne, Bartuzi Paulina, Melton Shelby D, Weber Axel, Ben-Shlomo Shani, Varol Chen, Raetz Megan, Mao Xicheng, Starokadomskyy Petro, van Sommeren Suzanne, Mokadem Mohamad, Schneider Heike, Weisberg Reid, Westra Harm-Jan, Esko Tõnu, Metspalu Andres, Kumar Vinod, Faubion William A, Yarovinsky Felix, Hofker Marten, Wijmenga Cisca, Kracht Michael, Franke Lude, Aguirre Vincent, Weersma Rinse K, Gluck Nathan, van de Sluis Bart, Burstein Ezra
Abstract excerpt
BACKGROUND & AIMS: Activation of the transcription factor nuclear factor-κB (NF-κB) has been associated with the development of inflammatory bowel disease (IBD). Copper metabolism MURR1 domain containing 1 (COMMD1), a regulator of various transport pathways, has been shown to limit NF-κB activation. We investigated the roles of COMMD1 in the pathogenesis of colitis in mice and IBD in human beings. METHODS: We...
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