Article
Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis.
Mucosal immunology - 1 Nov 2014
Demon D, Kuchmiy A, Fossoul A, Zhu Q, Kanneganti T-D, Lamkanfi M
Abstract excerpt
Ulcerative colitis and Crohn's disease are major inflammatory syndromes that affect millions of patients. Caspase-11 confers protection against Gram-negative enteropathogens, but its role during colitis is unknown. Here, we show that caspase-11 was constitutively expressed in the colon, and that caspase-11-deficient (caspase-11(-/-)) mice were hypersusceptible to dextran sodium sulfate (DSS)-induced colitis....
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