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Gut Microbiota Affects Sensitivity to Acute DSS-induced Colitis Independently of Host Genotype

7 Oct 2013

Abstract excerpt

Caspase-deficient mice and wild-type (WT) mice show significant differences in their gut microbiota composition. These differences coincide with the observation that caspase-3-deficient mice carrying a natural caspase-11 mutation (Casp3/11(-/-)) are less sensitive to acute dextran sodium sulfate-induced colitis than WT mice. For these reasons, we investigated the role of the microbiota in the development of...

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PMID: 24105395
DOI: 10.1097/mib.0b013e3182a8759a

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