Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Performance Evaluation of a Colorectal Cancer-Associated MassARRAY-Based Hotspot Genotyping Assay for KRAS, NRAS, BRAF, and PIK3CA Using Solid Tumor Specimens.

Frontiers in bioscience (Landmark edition) - 23 Jul 2026

Vashisht Vishakha, Vashisht Ashutosh, Mondal Ashis K, Ahluwalia Pankaj K, Farmaha Jaspreet, Woodall Jana, Kolhe Ravindra

Abstract excerpt

BACKGROUND: Accurate identification of actionable somatic variants is essential for therapeutic stratification in colorectal cancer (CRC). While next-generation sequencing (NGS) enables comprehensive genomic profiling, targeted approaches may provide faster and more practical alternatives for routine diagnostics. METHODS: This study evaluated the analytical performance of the Agena Bioscience iPLEX® High...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to GTP Phosphohydrolases

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Share to Reproducibility of Results

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 42530261
DOI: 10.31083/FBL53019

Genes

BRAF
KRAS
NRAS
PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Performance Evaluation of a Colorectal Cancer-Associated MassARRAY-Based Hotspot Genotyping Assay for KRAS, NRAS, BRAF, and PIK3CA Using Solid Tumor Specimens.PMID 42530261Read ↗

Genotyping of colorectal cancer for cancer precision medicine: Results from the IPH Center for Molecular Pathology.Semantic proximity Read ↗

Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics.Semantic proximity Read ↗

Detection of KRAS, NRAS and BRAF by mass spectrometry - a sensitive, reliable, fast and cost-effective techniqueSemantic proximity Read ↗

A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes.Semantic proximity Read ↗

Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry.Semantic proximity Read ↗

Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.Semantic proximity Read ↗

Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometrySemantic proximity Read ↗

Comprehensive assessment of actionable genomic alterations in primary colorectal carcinoma using targeted next-generation sequencing.Semantic proximity Read ↗

Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples.Semantic proximity Read ↗

Global mutational profiling of formalin-fixed human colon cancers from a pathology archive.Semantic proximity Read ↗

MSIplus for Integrated Colorectal Cancer Molecular Testing by Next-Generation Sequencing.Semantic proximity Read ↗

The potential of PIK3CA, KRAS, BRAF, and APC hotspot mutations as a non-invasive detection method for colorectal cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.