Article
Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry.
BMC medical genomics - 2 Oct 2020
Xu Chang, Peng Danli, Li Jialu, Chen Meihua, Hu Yujie, Hou Mingliang, Shang Qingjuan, Liang Qi, Li Jie, Li Wenfeng, Wu Xiaoli, Liu Changbao, Hu Wanle, Cai Mao, Zhang Huxiang, Chen Guorong, Yu Lingling, Zheng Xiaoqun, Jiang Feizhao, Luan Ju, Jin Shengnan, Ding Chunming
Abstract excerpt
BACKGROUND: Detection of somatic mutations in tumor tissues helps to understand tumor biology and guide treatment selection. Methods such as quantitative PCR can analyze a few mutations with high efficiency, while next generation sequencing (NGS) based methods can analyze hundreds to thousands of mutations. However, there is a lack of cost-effective method for quantitatively analyzing tens to a few hundred...
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