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The potential of PIK3CA, KRAS, BRAF, and APC hotspot mutations as a non-invasive detection method for colorectal cancer.

Molecular and cellular probes - 1 Jun 2022

Alizadeh-Sedigh Maryam, Mahmoodzadeh Habibollah, Fazeli Mohammad Sadegh, Haddadi-Aghdam Mohammad, Teimoori-Toolabi Ladan

Abstract excerpt

BACKGROUND: Early diagnosis of colorectal cancer (CRC) can lead to prompt treatment modalities. Circulating cell-free DNA (cfDNA) analysis provides an alternative non-invasive procedure for the study of the molecular profiles of the corresponding tumor tissue. In this study, we aimed to investigate PIK3CA, KRAS, BRAF, and APC hotspot mutations in CRC tumor tissue, besides evaluating the diagnostic performance of...

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PMID: 35296442
DOI: 10.1016/j.mcp.2022.101807

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