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Article

Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics.

Oncotarget - 13 Oct 2015

Magliacane Gilda, Grassini Greta, Bartocci Paola, Francaviglia Ilaria, Dal Cin Elena, Barbieri Gianluca, Arrigoni Gianluigi, Pecciarini Lorenza, Doglioni Claudio, Cangi Maria Giulia

Abstract excerpt

Tumor genotyping is an essential step in routine clinical practice and pathology laboratories face a major challenge in being able to provide rapid, sensitive and updated molecular tests. We developed a novel mass spectrometry multiplexed genotyping platform named PentaPanel to concurrently assess single nucleotide polymorphisms in 56 hotspots of the 5 most clinically relevant cancer genes, KRAS, NRAS, BRAF, EGFR...

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Identifiers

PMID: 26435479
DOI: 10.18632/oncotarget.5190
PMCID: PMC4741554

Genes

BRAF
EGFR
KRAS
NRAS

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