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Article

Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples.

Journal of translational medicine - 4 May 2016

Dallol Ashraf, Buhmeida Abdelbaset, Al-Ahwal Mahmoud Shaheen, Al-Maghrabi Jaudah, Bajouh Osama, Al-Khayyat Shadi, Alam Rania, Abusanad Atlal, Turki Rola, Elaimi Aisha, Alhadrami Hani A, Abuzenadah Mohammed, Banni Huda, Al-Qahtani Mohammed H, Abuzenadah Adel M

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a heterogeneous disease with different molecular characteristics associated with many variables such as the sites from which the tumors originate or the presence or absence of chromosomal instability. Identification of such variables, particularly mutational hotspots, often carries a significant diagnostic and/or prognostic value that could ultimately affect the therapeutic...

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Source

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Identifiers

PMID: 27146902
DOI: 10.1186/s12967-016-0878-9
PMCID: PMC4857423

Genes

EGFR
KRAS
APC
PTEN
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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