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Article

Comprehensive assessment of actionable genomic alterations in primary colorectal carcinoma using targeted next-generation sequencing.

British journal of cancer - 1 Oct 2022

Jan Yi-Hua, Tan Kien Thiam, Chen Shu-Jen, Yip Timothy Tak Chun, Lu Cu Tai, Lam Alfred King-Yin

Abstract excerpt

BACKGROUND: The clinical utility of comprehensive genomic profiling (CGP) for guiding treatment has gradually become the standard-of-care procedure for colorectal carcinoma (CRC). Here, we comprehensively assess emerging targeted therapy biomarkers using CGP in primary CRC. METHODS: A total of 575 primary CRCs were sequenced by ACTOnco® assay for genomic alterations, tumour mutational burden (TMB), and...

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PMID: 35842545
DOI: 10.1038/s41416-022-01913-4
PMCID: PMC9519871

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