Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and cross-species single-cell analyses prioritize CD83 in antigen-presenting cells as a candidate therapeutic target in asthma.

Frontiers in immunology - 1 Jan 2026

Qian Guojun, Xu Qiaoyi, Zhu Xuejiao, Tao Yiying, Ding Xibing, Zhu Hao, Zhang Song, Zhan Qionghui, Xu Saihong, Song Yan, Hu Qin, Fang Hongwei, Fan Yinghui, Tian Jie, Yu Weifeng

Abstract excerpt

Background: Asthma remains a heterogeneous inflammatory airway disease, and current therapies, including biologics, benefit only selected patient subsets. We aimed to identify genetically supported therapeutic targets with clear mechanistic and translational relevance in asthma. Methods: We integrated cis-eQTL and cis-pQTL instruments for 585 druggable genes with asthma genome-wide association data from FinnGen,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen-Presenting Cells
Share to Antigens, CD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asthma

Share to CD83 Antigen

Share to Immunoglobulins

Share to Macaca fascicularis

Share to Membrane Glycoproteins

Share to Single-Cell Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42516377
DOI: 10.3389/fimmu.2026.1859076
PMCID: PMC13402173

Genes

CD83

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and cross-species single-cell analyses prioritize CD83 in antigen-presenting cells as a candidate therapeutic target in asthma.PMID 42516377Read ↗

Multimodal gene prioritization reveals nonlinear regulatory architecture in childhood-onset asthmaSemantic proximity Read ↗

Multiomics Approach Identifies Novel Genetic Determinants and Therapeutic Targets for Asthma.Semantic proximity Read ↗

Single-Cell Mendelian Randomization Identifies Cell-Type Specific Genetic Drivers of Lung Cancer SubtypesSemantic proximity Read ↗

Trans-regulatory gene mapping prioritizes disease drivers in asthma.Semantic proximity Read ↗

Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.Semantic proximity Read ↗

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associationsSemantic proximity Read ↗

A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.Semantic proximity Read ↗

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations.Semantic proximity Read ↗

Disease-Specific Integration of Omics Data to Guide Functional Validation of Genetic Associations.Semantic proximity Read ↗

A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthmaSemantic proximity Read ↗

Large-scale Genetic Analysis Identifies 66 Novel Loci for AsthmaSemantic proximity Read ↗

Prediction and characterization of genetically regulated expression of asthma tissues from African-ancestry populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.