Article
Trans-regulatory gene mapping prioritizes disease drivers in asthma.
Cell - 20 Aug 2026
Salamone Isabella M, Tian Peixin, Qi Zining, Zhao Jiaqi, Zhang Li, Tan Qilong, Li Jinghui, Michael Ashley N, Thornburg Alexis G, Sakabe Noboru J, Minogue Mark, Weber Zachary T, Chen Bohao, Ciszewski Cezary, He Xin, Shah Hardik, Vercelli Donata, Ober Carole, Lin Hening, Liu Zhonghua, Nóbrega Marcelo A, Liu Xuanyao
Abstract excerpt
Deciphering which genes are most important to disease etiology is a central challenge in human genetics. While genome-wide association studies have cataloged thousands of variants, it's been proposed that most are indirect regulators of a limited, currently unidentified set of central disease-driving genes, defined here as disease-proximal genes (DPGs). Here, we introduce DANDELION, a mediation-inspired...
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