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Article

Prediction and characterization of genetically regulated expression of asthma tissues from African-ancestry populations.

The Journal of allergy and clinical immunology - 1 Jan 2026

Slack Sarah D, Esquinca Erika, Arehart Christopher H, Boorgula Meher Preethi, Szczesny Brooke, Romero Alex, Campbell Monica, Chavan Sameer, Rafaels Nicholas, Watson Harold, Landis R Clive, Hansel Nadia N, Rotimi Charles N, Olopade Christopher O, Figueiredo Camila A, Ober Carole, Liu Andrew H, Kenny Eimear E, Kammers Kai, Ruczinski Ingo, Taub Margaret A, Daya Michelle, Gignoux Christopher R, Kechris Katerina, Barnes Kathleen C, Mathias Rasika A, Johnson Randi K

Abstract excerpt

BACKGROUND: Genetic control of gene expression in asthma-related tissues is not well characterized, particularly for African-ancestry populations, limiting advancement in our understanding of the increased prevalence and severity of asthma in these populations. OBJECTIVE: We sought to create novel transcriptome prediction models for asthma tissues (nasal epithelium and CD4+ T cells) and apply them in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40930298
DOI: 10.1016/j.jaci.2025.07.035

Genes

CD4
CCNC
IL33
LTC4S
MUC5AC
SCGB1A1
ZNF366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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