Article
Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.
BMC medical genomics - 2 Aug 2014
Bunyavanich Supinda, Schadt Eric E, Himes Blanca E, Lasky-Su Jessica, Qiu Weiliang, Lazarus Ross, Ziniti John P, Cohain Ariella, Linderman Michael, Torgerson Dara G, Eng Celeste S, Pino-Yanes Maria, Padhukasahasram Badri, Yang James J, Mathias Rasika A, Beaty Terri H, Li Xingnan, Graves Penelope, Romieu Isabelle, Navarro Blanca del Rio, Salam M Towhid, Vora Hita, Nicolae Dan L, Ober Carole, Martinez Fernando D, Bleecker Eugene R, Meyers Deborah A, Gauderman W James, Gilliland Frank, Burchard Esteban G, Barnes Kathleen C, Williams L Keoki, London Stephanie J, Zhang Bin, Raby Benjamin A, Weiss Scott T
Abstract excerpt
BACKGROUND: Allergic rhinitis is a common disease whose genetic basis is incompletely explained. We report an integrated genomic analysis of allergic rhinitis. METHODS: We performed genome wide association studies (GWAS) of allergic rhinitis in 5633 ethnically diverse North American subjects. Next, we profiled gene expression in disease-relevant tissue (peripheral blood CD4+ lymphocytes) collected from subjects...
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