Article
A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma.
Human molecular genetics - 1 Jun 2015
Sharma Amitabh, Menche Jörg, Huang C Chris, Ort Tatiana, Zhou Xiaobo, Kitsak Maksim, Sahni Nidhi, Thibault Derek, Voung Linh, Guo Feng, Ghiassian Susan Dina, Gulbahce Natali, Baribaud Frédéric, Tocker Joel, Dobrin Radu, Barnathan Elliot, Liu Hao, Panettieri Reynold A, Tantisira Kelan G, Qiu Weiliang, Raby Benjamin A, Silverman Edwin K, Vidal Marc, Weiss Scott T, Barabási Albert-László
Abstract excerpt
Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved in complex diseases. Still, the detailed understanding of the molecular and physiological mechanisms through which these genes affect disease phenotypes remains a major challenge. Here, we identify the asthma disease module, i.e. the local neighborhood of the interactome whose perturbation is associated...
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