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Article

Rethinking disomy: Autosomal expression bias.

The Journal of experimental medicine - 6 Apr 2026

Bogunovic Dusan

Abstract excerpt

Humans are disomic. At birth, all nucleated cells in the body have the same genetic material, composed of 22 pairs of autosomes and a pair of sex chromosomes. Half the chromosomes are maternal, and half are paternal. It is thought that the two copies of autosomal genes are equally transcribed and translated in a given cell. This notion, based on Mendelian genetics, has guided the identification of genetic...

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PMID: 41870367
DOI: 10.1084/jem.20241044

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